腹膜化學治療

腹膜治療的條件是要做完手術後，要盡量確認沒有大於一公分的腫瘤，再進行腹膜治療才比較有效。如果目前照長庚醫師說法，復發的時候再做腹膜治療，意思就是會再開第二次刀，然後做腹膜治療。

根據研究指出，腹膜化療比一般注射化療，可以多活15.9個月，但腹膜生活品質(副作用強)在前幾週很差，但治療一年後就能恢復正常生活，況且，腹膜若副作用過大，也可以馬上改回靜脈注射。

參考出處

Patients with optimally debulked (≤1 cm) stage III ovarian cancer after front-line surgery should be offered intraperitoneal (IP) chemotherapy. The Gynecological Oncology Group (GOG) trial compared IV cisplatin and paclitaxel with IP cisplatin and paclitaxel; results showed that IP therapy improved survival and yielded a 25% reduction in the risk of death. However, the trial also showed that IP chemotherapy resulted in increased toxicity compared with IV chemotherapy.^[8]

At this time, there is no standardized regimen for IP therapy; however, the following dosing regimens may be used:

• Paclitaxel 135 mg/m ² IV over 24 h on day 1 plus  cisplatin 100 mg/m ² IP on day 2 (may reduce dose to 75 mg/m ²) plus  paclitaxel 60 mg/m ² IP on day 8 for six or more cycles, provided that the disease is responsive ^[8] 
• The cisplatin dose may be reduced to 75 mg/m ² IP on day 2; some clinicians give paclitaxel 135 mg/m ² IV over 3 h followed by cisplatin 75 mg/m ² IP, both on day 1 and on an outpatient basis ^[9] 
• Normal range of carboplatin AUC for treatment of ovarian carcinoma is from 5 to 7.5; patients who have received extensive prior chemotherapy or radiation should start with an AUC < 5 

If patient cannot tolerate IP delivery, revert to one of the following two drug regimens:

• Paclitaxel 175 mg/m ² IV over 3 h plus  carboplatin AUC 7.5 IV over 1 h on day 1; every 21 d for six cycles ^[10] or 
• Docetaxel 75 mg/m ² IV over 1 h plus  carboplatin AUC 5 IV over 1 h on day 1; every 21 d for six cycles ^[6]